Embodying Business Sustainability: 10 Sustainable Tech Startups in the USA

Sustainability in business has moved from the periphery to the core of strategic business management in the 21st century. What was initially viewed as a niche concern later encompassed several business practices designed to reduce environmental impact, ensure economic viability, and promote social equity. Influenced by the growing recognition that sustainable practices are ethically imperative and beneficial for long-term business success, companies have embraced them in various forms.

At The Silicon Journal,  we champion the vital role of sustainability in business, spotlighting eco-friendly practices through our profiles, articles, and blogs. As a trusted business publication, we inspire companies to embrace the latest sustainability trends and lead the way toward a greener future.

Introduction

Managers in businesses are aiming to strike a balance among economic, ecological, cultural, and social value creation in their business models. Consumers nowadays are more informed and concerned about the environmental and social impacts of their purchases, leading to a demand for transparency and ethical conduct from brands. On the other hand, regulatory frameworks are getting stricter globally, encouraging corporate sustainability through penalties and incentives. In terms of investment, investors prioritize companies with strong ESG or ‘Environmental,’ ‘Governance,’ and ‘Social.’

Companies, including startups across various industries, are now adopting sustainable practices and engaging in corporate social responsibility (CSR) initiatives. Technology, being a foundation for promoting sustainable business practices, has remained at the forefront of transforming conventional business practices into sustainable ones. Companies operating in the technology sector, including startups, are taking sustainability to the next level with their innovative practices. By creating solutions that minimize environmental impact, foster long-term socio-economic benefits, and promote resource efficiency by leveraging technology such as IoT and artificial intelligence (AI), tech startups are ensuring sustainability in their practices. This article will inform readers about the top 10 sustainable tech startups in the USA that are demonstrating exceptional sustainability practices by leveraging technology.

Top Sustainable Tech Startups of 2025: Reimagining Sustainability in the USA

1. Inato

Inato is bringing clinical research closer to all patients, regardless of their location and economic status. Inato’s mission is to accelerate the pace of medical innovation. Its AI-powered platform is made to connect community-based research centers to trials worldwide, aiming for improved visibility and accessibility across a diverse population. 

2. Uncharted Power

Uncharted Power uses renewable kinetic energy solutions to generate consistent, clean, and cost-efficient power. It is on a mission to raise the standard of living for everyone. It works to accelerate the equitable development of smart and sustainable infrastructure. Built on the values of intelligence, inclusivity, equity, and sustainability, the company is committed to creating an environment where everyone feels respected, welcomed, and supported.

3. Apeel Sciences

Apeel Sciences is a well-recognized sustainable tech startup in the world of agriculture, food, sustainability, and innovation. By addressing the issues of hunger and food waste, Apeel Sciences produces fresh fruits and vegetables, using peels, seeds, and pulps of all plants. As a sustainable company, it has prevented 166 million pieces of fruit from waste, avoided 29.1K metric tons of CO2 emissions, and conserved 6.9 billion liters of water. 

4. Arzeda

This Seattle-based biotechnology company is the leading Protein Design Company™ that leverages AI-powered protein design to deliver innovative proteins and enzymes for industrial applications. Arzeda is making an impact across industries, from food to personal care, fashion, and pharma.  Its proteins reduce the carbon footprint, develop food ingredients that can be produced more efficiently, and develop proteins that enhance the durability, feel, and functionality of materials.

5. Bolt Threads

Bolt Threads leverages natural proteins to create materials, including xl-silk™, xl-silk™. By addressing a resource-constrained world, the company turns natural materials into incredible products. By adopting a holistic approach to its process and pioneering greener practices, Bolt Threads improves the impact of its materials.

6. Recycle Track Systems

Recycle Track Systems is championing a better way to manage waste and recycling. By combining digital solutions with high-touch service, RTS makes waste disposal easier, responsible, and smarter. It helps companies track and optimize their pickups, from on-demand removal to fully integrated waste management solutions.

7.  Biome Makers

Biome Makers recovers soil health as a step towards a more sustainable future. This tech-driven, sustainable startup is dedicated to improving the world’s soil health by working on one farm at a time. Through detailed reporting and analytics, it helps farmers by delivering statistics on soil fertility, soil health, and biodiversity to make impactful changes.  

8. Radiant

Radiant is a clean energy startup that helps build a nuclear microreactor. It has produced a climate-friendly alternative to diesel generators, the Kaleidos 1MW microreactor. This is the world’s first zero-emission, portable power source that works anywhere.  

9. EcoCart

EcoCart is an eco-friendly e-commerce platform that offers a sustainable shopping experience for customers. From bundled returns to shipping protection, EcoCart serves it differently. Through its sustainable practices, the company has mitigated over 400 million pounds of greenhouse gases. More than 2k merchants are choosing EcoCart in their movement against climate change. 

10. Crusoe

Crusoe is the best among all the startup green data centers 2025 must watch. Its data centers are purpose-built to tackle the most intensive AI workloads. Engineered for the future of AI, this tech-based sustainability data center has a data capacity of 946K GPUs and an electricity capability of 3.4 Gigawatts.